Estrogen Connection

In the USMLE Pass Program Notes. Dr. Francis is a master. He Explained here the Estrogen Connection in a cardiac physiology class Why does a adolescent female have a dilated heart? •She is an a period in her life that has ↑↑↑ Estrogen = (+) S3 It is greater than males = Dont have an S3. •Therefore, Estrogen must be a MUSCLE RELAXANT!!! •Estrogen is a muscle relaxant and will cause: - S3 - Constipation in pregnancy - urinary retention - DVT - hemrroids - reflux - Relaxed gall bladder (gall stones) - Hips expand - Muscles are weaker - GLOW → d/t vasodilation •Example: The most common presentation of pregnancy is weakness and SOB, most common cause of death is HF... → neuromuscular weakness •Estrogen will protect the heart in women by causing vasodialtion and LOW BP •Estrogen is broken down by the liver (p450) → Anyone with liver failure will have a high estrogen state and will present with the above symptoms •Cirrhosis → ↑ estrogen levels oGynecomastia oSpider telangectsia oTesticular atrophy oCOMA